Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

Valter D. Longo and Satchidananda Panda, Perspective – Cell Metabolism, 23, June 14, 2016

Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources.

Both intermittent and periodic fasting result in benefits ranging from the prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which food consumption is restricted to certain hours of the day, allows the daily fasting period to last >12 hr, thus imparting pleiotropic benefits.

Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting-mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMDs, both basic science and translational research are warranted to develop fasting-associated interven-tions into feasible, effective, and inexpensive treatments with the potential to improve healthspan

Cell Press May 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Dietary Interventions, Cardiovascular Aging, and Disease Animal Models and Human Studies

Hamed Mirzaei, Stefano Di Biase, Valter D. Longo, Circ Res. 2016;118:1612-1625.

Recent studies indicate that dietary interventions have the potential to prevent and even treat cardiovascular disease, which is the leading cause of death.

Many of these studies have focused on various animal models that are able to recreate one or more conditions or elevate risk factors that characterize the disease.

Here, we highlight macronutrient-focused interventions in both mammalian model organisms and humans with emphasis on some of the most relevant and well-established diets known to be associated with cardiovascular disease prevention and treatment.

We also discuss more recent dietary interventions in rodents, monkeys, and humans, which affect atherosclerosis and cardiovascular diseases with focus on those that also delay aging.

BioMed Central 2016

Safety and feasibility of fasting in combination with platinum-based chemotherapy

Cell Press July 2016

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

JAMA 2016

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality