ProLon^® is the first Fasting Mimicking Diet™ (FMD™) developed to provide the beneficial effects of fasting by making the fasting mimicking period safe and pleasant. ProLon^®, which contains plant-based soups, bars, crackers, olives, drinks, and supplements, is a proprietary 5-day dietary program, providing approximately 750 to 1100 calories per day. It is based on innovative research carried out at two of the world’s leading centers for biomedical and longevity research located at the University of Southern California (USC), the Longevity Institute and the Diabetes and Obesity Research Institute. This revolutionary meal plan has been scientifically designed and clinically tested to mimic the effects of fasting, while providing the proper daily nourishment and the feeling of satisfaction.

ProLon^® was shown in clinical trials to have beneficial effects on a wide variety of markers: it decreases abdominal fat while increasing relative lean body mass, decreases fasting glucose, reduces C-reactive protein (a marker of inflammation), and reduces IGF-1 (associated with increased DNA damage mortality and aging in humans).

A Fasting Mimicking Diet™ (FMD™) is a high nutrition, low protein, low carbohydrate meal plan, clinically proven to beneficially change a wide range of biomarkers associated with aging, poor health, and inflammation. (See Question 2).

The diet should be taken for 5 consecutive days, after which the patient will transition for 1 day and then resume their normal diet. Instructions are provided in every carton. A specific combination of food is provided on each day for breakfast, lunch, dinner and snacks. All food provided on a specific day should be taken on that day only. While a meal missed can be made up at any time during the same day, there should be no carryover from one day to the next. The 5-day diet should be taken as often as is recommended by the health care provider.

The amount of weight loss varies by individual. A healthcare professional will be able to discuss this during consultation and work with the patient on meeting weight goals.

Depending on the medical illness or disease, past medical history, and current medications, the ProLon^® dietary program might be combined with the standard of care treatment; however, ProLon^® cannot be prescribed to prevent or treat diseases. Contact the healthcare practitioner most familiar with the illness or disease to discuss the ProLon^® dietary program.

As the ProLon^® dietary program is designed to provide all of the supplements and nutrients needed, no additional multivitamins or supplements should be taken during the diet period; however, the options should be discussed with the supervising health care provider.

The ProLon^® dietary program should be administered under the supervision of a licensed health care provider (HCP), e.g. Medical Doctor, Doctor of Osteopathic Medicine, Physician Assistant, Nurse Practitioner, a Doctor of Integrative Medicine, Anti-Aging Specialist, Naturopath, Chiropractor or Registered Dietitian. As this is a low calorie diet, that supervising HCP must clear the individual to participate in the program. If the HCP does not feel qualified to clear the patient, they should seek clearance from a qualified HCP, such as a medical doctor. In addition, they should determine if the individual has any known medical conditions, and if so, obtain medical clearance from the HCP treating the patient’s condition before initiating the ProLon^® diet.

Healthcare professionals who desire to sell or authorize patients to purchase ProLon^® must first register on the ProLon^® website, www.ProLon.com.au. This is an easy, one-time process.

1. Click on the Register button on the Home Page.
2. Select Healthcare Professional registration.
3. Create a User ID and Password.
4. Complete the short form.
5. Review, complete, and sign the ProLon^® Purchase Agreement.

You will then be able to order, refill orders or authorize patients to purchase ProLon^®from the website.

In order to obtain ProLon^®, an individual should first discuss the dietary program with her/his health care provider (HCP) and obtain authorization to receive ProLon^®. If the HCP has not yet registered on the ProLon^® website they must do so (see Question 9). If they have and have pre-ordered ProLon^®, then the individual can pick it up at the doctor’s office. Otherwise, the HCP can easily place an order on the ProLon^® website to be delivered to the clinic for pickup or directly to the patient’s home. An HCP can also provide an online authorization for the patient to order ProLon^® from the website and have it delivered directly to the patient.

During the consultation with potential ProLon^® users, the supervising health care provider should determine if a low calorie and low protein diet lasting 5 days would be safe for patients based on their medical history and health conditions. The supervising physician should educate the patient about potential side effects, and provide contact information to enable the patient to contact him/her if any medical condition arises. Also, the healthcare provider might consider following up with the participants during the ProLon^® diet cycle to ensure that patients are following the diet correctly. (See Question 14.)

This depends on the patient’s baseline markers and health measurements, assessment and recommendation of the healthcare professional; for the majority of relatively healthy individuals, 3 to 4 times a year is sufficient. By contrast, for individuals with high levels of multiple biomarkers for aging, cholesterol, IGF-1, CRP, blood pressure, abdominal fat, etc., the HCP may decide to recommend 6-12 ProLon^® cycles a year. For very high risk patients it may be given as often as every 15 days.

Splitting up days is not recommended since this method is believed to be much less effective than the 5 consecutive days.

On Day 6, after the ProLon^® diet ends, users should avoid binge eating and resume their normal diet gradually. They should start with liquid foods, such as soups and fruit juices, followed by light meals, including rice, pasta and small portions of meat, fish and/or legumes. A normal diet can be resumed on day 7, or 24 hours after the end of the ProLon^® diet.

The results achieved with ProLon^® in clinical trials were very similar to those achieved with fasting. However, ProLon^® is safer, providing vital nutrition during the 5 day diet.

The proprietary dietary formulation is based on decades of scientific research, including preclinical and clinical trials and contains specific ingredients that were put together to mimic fasting, while optimizing nourishment.

The healthcare professional (HCP) should make recommendations based on the individual; however, the patient may want to record their weight, blood pressure, and abdominal circumference before starting and after each cycle of the diet. Also, the HCP may want to remind the patient to take the diet as planned, but if they miss something to record that and inform the HCP. Someone who wants to track their calorie intake and other parameters might want to try the app “Lose It” (www.loseit.com).

The meal plan contains some products that are made with organic ingredients, but they are not certified organic. Our food products are all plant based.

As the ProLon^® dietary program provides all one needs for nourishment during the 5 days, while letting the powerful self-repair and rejuvenation mechanisms work, no extra foods or drinks (other than water and decaffeinated tea) should be consumed while on ProLon^® to avoid reducing its efficacy.

One should not eat anything extra while on the ProLon^® dietary program. Since this diet is low calorie, one may experience the feeling of slight weakness and possible dizziness as the body adjusts, especially on Day 2. This is normal. Usually by day 3 this decreases; however, should the symptoms be severe, one can drink fruit juices and call your doctor or 911 for emergencies. The supervising healthcare professional should then review if it is safe for the patient to continue on the diet. The energy drink provided in the diet boxes, to be taken throughout the day, provides not only nutritional support during the diet, but can be specifically helpful in these instances.

Because the ProLon^® diet is low in calories, hunger may occur during the 5 day diet period. Most clinical trial participants only experienced a low level of periodic hunger. If hunger is severe, the patient should contact their healthcare professional. In such cases, one may want to consume a food that is not highly caloric, such as a slice of an apple. Remember, this diet is only for 5 days. Feeling hungry is normal if one’s normal diet consists of high calories. People generally reported that the hunger subsided by day 3 or 4.

Because coffee can interfere with the beneficial effects of the diet, it is not recommended to be consumed with ProLon^®. However, if one must have coffee, we recommend minimizing coffee consumption to 1 cup per day.

There are different flavors of teas provided with the diet. Although not recommended, since the ProLon^® teas are selected for specific properties and have been clinically tested, if for some reason one does not want to consume one of these flavors, a substitution can be made. A substitute tea should have no caffeine or additives, and should be taken without sugar or cream.

Yes; however, since this diet has been clinically tested, one should make every effort to follow the program to minimize malnourishment and safety issues. Just document the foods not eaten and inform the supervising healthcare professional.

Yes, if a meal is missed, it can be taken later on the same day; but do not take a missed meal on a different day. (See Question 26.)

This is not advised; the foods provided should only be consumed on the day for which they are designated; however, if feeling lightheaded, dizzy or having any other side effects, consuming one of the leftover diet foods would be preferable to consuming something else. Note: the ProLon^® diet does not have extras in the meal box. (See Question 20.)

The positive effects of the ProLon^® dietary program tested in the clinical trials require 5 consecutive days. Therefore, the diet should be maintained for the full 5 days. If the diet must be discontinued earlier, however, the healthcare professional should be informed.

The diet is formulated based on specific nutritional, scientifically proven benefits. Therefore, it’s very important to follow the diet closely. However, if this happens on one occasion, do not worry—continue with the ProLon^® dietary program for the rest of the 5 days.

It depends on the food item. For example, if a soup is disliked, lemon/lime and herbs can be added in small quantities. If a tea is disliked, a different tea can be substituted, provided it is non-caffeinated, non-sugared, preferably with no added color or preservatives.

Yes, herbs and lemon in small quantities may be added to taste. Please note that the diet is specially formulated to provide a specific amount of nutrients and calories.

DHA stands for docosahexaenoic acid and is an omega-3 fatty acid. DHA is essential for normal brain function.

The energy drink is specially formulated to provide vegetable-based nutritional support during the diet.

The energy drink is made from plant-derived glycerol and water. This selection is the result of years of studies to maximize safety and nourishment without interfering with the beneficial effects of the diet.

The unique design and combination of ingredients in ProLon^® enables the diet to promote the generation of an increased number of stem cells and a wide range of “anti-aging” effects, some caused by nourishment and some caused by triggering rejuvenating effects.

The ProLon^® dietary program is free of lactose and gluten; so people who are lactose or gluten intolerant are able to take the diet. Participants with food allergies such as nuts, soy, tomato, or with any other known allergies to the ingredients, should avoid consuming ProLon^® or wait until a version of ProLon^® is produced that is free of allergens.

We recommend you discuss your ongoing diet with your healthcare professional. They can review your current intake and give you specific guidelines to follow based on your height, weight and gender. During the 5 day ProLon^® dietary program, approximately 1100 calories are consumed on Day 1 and 750 calories on Days 2-5.

Patients can buy multiple cartons of ProLon^® at one time and receive quantity discounts. (Each carton contains everything needed for the 5-Day cycle.) Cartons will only be shipped one at a time to ensure freshness and maximum potency. As long as the cartons were never shipped to the patient, a full refund—minus the discount that he/she would not have qualified for—will be applied.